The Maudsley Prescribing Guidelines in Psychiatry

The Maudsley Prescribing Guidelines in Psychiatry 13th Edition

By: David M. Taylor, Thomas R. E. Barnes, Allan H. Young

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Publication Details

Edition: 13th

Details: Paperback, 872 pages.

Publication date: 07/05/2018

Publisher: Wiley-Blackwell

ISBN: 9781119442608

Publication Status: Out Of Print

Publication Description


The revised 13th edition of the essential reference for the prescribing of drugs for patients with mental health disorders

The revised and updated 13th edition of The Maudsley Prescribing Guidelines in Psychiatry provides up-to-date information, expert guidance on prescribing practice in mental health, including  drug choice, treatment of adverse effects and how to augment or switch medications. The text covers a wide range of topics including pharmacological interventions for  schizophrenia, bipolar disorder, depression and anxiety, and many other less common conditions. There is advice on prescribing in children and adolescents, in substance misuse and in special patient groups. 

This world-renowned guide has been written in concise terms by an expert team of psychiatrists and specialist pharmacists. The Guidelines help with complex prescribing problems and include information on prescribing psychotropic medications outside their licensed indications as well as potential interactions with other medications and  substances such as alcohol, tobacco and caffeine. In addition, each of the book’s 165 sections features a full reference list so that evidence on which guidance is based can be readily accessed. This important text:

  • Is the world’s leading clinical resource for evidence-based prescribing in day-to-day clinical practice and for formulating prescribing policy
  • Includes referenced information on topics such as transferring from one medication to another, prescribing psychotropic medications during pregnancy or breastfeeding, and treating patients with comorbid physical conditions, including impaired renal or hepatic function.
  • Presents guidance on complex clinical problems that may not be encountered routinely

Written for psychiatrists, neuropharmacologists, pharmacists and clinical psychologists as well as nurses and medical trainees, The Maudsley Prescribing Guidelines in Psychiatry are the established reference source for ensuring the safe and effective use of medications for patients presenting with mental health problems. 

About the Author

David M. Taylor BSc, MSc, PhD, FFRPS, FRPharmS, is Director of Pharmacy and Pathology at the Maudsley Hospital and Professor of Psychopharmacology at King's College, London.

Thomas R. E. Barnes, MBBS, MD, FRCPsych, DSc, is Emeritus Professor of Clinical Psychiatry at Imperial College London and joint-head of the Prescribing Observatory for Mental Health at the Royal College of Psychiatrists' Centre for Quality Improvement.

Allan H. Young, MB, ChB, MPhil, PhD, FRCPC, FRCPsych, is Chair of Mood Disorders and is Director of the Centre for Affective Disorders in the Department of Psychological Medicine in the Institute of Psychiatry at King's College London, UK.

Table of Contents

Part 1:  Drug treatment of major psychiatric conditions

Chapter 1:  Schizophrenia and related psychoses


General introduction

General principles of prescribing

Minimum effective doses

Licensed maximum doses

Equivalent doses

High-dose antipsychotics: prescribing and monitoring

Combined antipsychotics

Antipsychotic prophylaxis

Negative symptoms


Relative adverse effects – a rough guide

Treatment algorithms for schizophrenia

First-generation antipsychotics – place in therapy

NICE guidelines for the treatment of schizophrenia

Antipsychotic response – to increase the dose, to switch, to add or just wait – what is the right move?

Acutely disturbed or violent behaviour

Antipsychotic long-acting injections

Depot antipsychotics – pharmacokinetics

Management of patients on long-term depots

Aripiprazole long-acting injection

Olanzapine long-acting injection

Paliperidone palmitate long-acting injection

Risperidone long-acting injection

Omega-3 fatty acid (fish oils) in schizophrenia


Extrapyramidal symptoms


Weight gain

Treatment of antipsychotic-induced weight gain

Electroconvulsive therapy and psychosis

Neuroleptic malignant syndrome


QT prolongation


Diabetes and impaired glucose tolerance

Blood pressure changes



Sexual dysfunction


Switching antipsychotics

Venous thromboembolism


Clozapine initiation schedule

Optimising clozapine treatment

Alternatives to clozapine

Re-starting clozapine after a break in treatment

Initiation of clozapine for community-based patients


Clozapine: common adverse effects

Clozapine: uncommon or unusual adverse effects

Clozapine: serious haematological and cardiovascular adverse effects

Clozapine-induced hypersalivation

Clozapine-induced gastrointestinal hypomotility (CIGH)

Clozapine, neutropenia and lithium

Clozapine and chemotherapy

Chapter 2:  Bipolar disorder




Antipsychotic drugs in bipolar disorder

Antipsychotic long-acting injections in bipolar disorder

Physical monitoring for people with bipolar disorder

Treatment of acute mania or hypomania

Rapid-cycling bipolar disorder

Bipolar depression

Prophylaxis in bipolar disorder

Chapter 3:  Depression and anxiety disorders

Chapter 4 Addictions and substance misuse


Alcohol dependence

Opioid dependence

Nicotine and smoking cessation

Pharmacological treatment of dependence on stimulants

GHB and GBL dependence

Benzodiazepine misuse

Synthetic cannabinoid receptor agonists (SCRAs)

Interactions between ‘street drugs’ and prescribed psychotropic drugs

Drugs of misuse – a summary

Part 2:  Drug treatment of special patient groups

Chapter 5 Children and adolescents

Principles of prescribing practice in childhood and adolescence

Depression in children and adolescents

Bipolar illness in children and adolescents

Psychosis in children and adolescents

Anxiety disorders in children and adolescents

Obsessive compulsive disorder (OCD) in children and adolescents

Post-traumatic stress disorder in children and adolescents

Attention deficit hyperactivity disorder

Autism spectrum disorders

Tics and Tourette’s syndrome

Melatonin in the treatment of insomnia in children and adolescents

Rapid tranquillisation (RT) in children and adolescents

Doses of commonly used psychotropic drugs in children and adolescents

Chapter 6 Prescribing in older people

General principles


Safer prescribing for physical conditions in dementia

Management of behavioural and psychological symptoms of dementia

A guide to medication doses of commonly used psychotropic drugs in older adults

Covert administration of medicines within food and drink

Chapter 7:  Pregnancy and breastfeeding

Drug choice in pregnancy


Chapter 8:  Hepatic and renal impairment

Hepatic impairment

Renal impairment

Part 3:  Prescribing in specialist conditions

Chapter 9:  Drug treatment of other psychiatric conditions

Borderline personality disorder

Eating disorders


Chapter 10:  Drug treatment of psychiatric symptoms occurring in the context of other disorders

General principles of prescribing in human immunodeficiency virus (HIV)

Prescribing psychotropics in HIV


22q11.2 Deletion syndrome

Learning disabilities

Huntington’s disease

Multiple sclerosis

Parkinson’s disease

Atrial fibrillation

Bariatric surgery

Part 4:  Other aspects of psychotropic drug use

Chapter 11 Pharmacokinetics

Plasma level monitoring of psychotropic drugs

Interpreting post-mortem blood concentrations

Acting on clozapine plasma concentration results

Psychotropic drugs and cytochrome (CYP) function

Smoking and psychotropic drugs

Drug interactions with alcohol

Chapter 12 Other substances



Chapter 13:  Psychotropic drugs in special conditions

Psychotropic drugs in overdose

Driving and psychotropic drugs

Psychotropic drugs and surgery

Chapter 14:  Miscellany

Enhancing medication adherence

Re-starting psychotropic medications after a period of non-compliance

Biochemical and haematological effects of psychotropic medications

Summary of psychiatric adverse effects of non-psychotropic medications

Prescribing drugs outside their licensed indications (‘off-label’ prescribing)

The Mental Health Act in England and Wales

Site of administration of intramuscular injections

Read more


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